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Tregs in the tumor microenvironment: A friend or a foe?

CD4+ Regulatory T (Treg) cells suppress excessive immune responses thus maintain sanity in the host immune system. Cancer cells take…
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Death by Dimensions

In this big data era, the importance of statistics does not need any mention. It helps us make sense of…
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EZH2 inhibitors sensitize HR proficient ovarian cancers to PARP inhibitors

Homologous recombination (HR) is a precise DNA repair mechanism, which is impaired in BRCA-mutant tumors. PARP inhibitors are effective against…
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Cancer Vaccines — A Promising Prospect

Cancer vaccines Since the discovery, vaccines have proven effective in fading off some of the deadliest diseases, saving a countless…
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The Correlation Conundrum!

The recent shift in funding policies favoring translational-over-basic research has forced researchers to associate their gene/protein of interest to diseases…
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Kaplan-Meier plot and the survival statistics

Once every five years, Nepal hosts a festival where Hindu devotees from Nepal and India gather in a small village…
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Puzzling out the STING activation in cancer

Following up on the previous blog (STING the Cancer). Here, I summarize a recent paper from Linda et al. published…
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How to turn cancer cells into fat?

Given a choice between gaining some fat vs having metastatic cancer, what would you choose? For a cancer patient, this…
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STING the Cancer

If you had attended the American Association of Cancer Research (AACR) annual meeting this year (2019), you must have noticed…
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Microbiota to the cancer rescue

Immunotherapy has changed the landscape of cancer treatment with complete tumor remission in a subset of patients. While immense efforts…
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